TABLE OF CONTENTS

PART I ………………………………………………………………………………………………………………..1
A. Introduction: a brief history of autoregulation research …………………………………….1
B. Cerebral blood flow regulation and physiology………………………………………………..8
C. Methods to measure cerebral autoregulation ………………………………………………….17
D. Autoregulation indices and signal processing…………………………………………………22
E. Comparisons between autoregulatory indices ………………………………………………..28
F. Optimal cerebral perfusion pressure ……………………………………………………………..29
PART II……………………………………………………………………………………………………………..37
A. Subarachnoid hemorrhage …………………………………………………………………………..37
B. Clinical relevance of autoregulation following subarachnoid hemorrhage …………45
C. Pilot study on autoregulation monitoring in subarachnoid hemorrhage ……………..51
D. Results of the subarachnoid hemorrhage pilot study ……………………………………….65
E. Discussion …………………………………………………………………………………………………89
PART III ……………………………………………………………………………………………………………95
A. Large-vessel occlusion (LVO) ischemic stroke ………………………………………………95
B. Clinical relevance of autoregulation following ischemic stroke ………………………..99
C. Pilot study on autoregulation monitoring in ischemic stroke ………………………….103
D. Results of the ischemic stroke pilot study…………………………………………………….111
E. Discussion ……………………………………………………………………………………………….122
PART IV ………………………………………………………………………………………………………….131
A. Concluding remarks and future studies………………………………………………………..131
References ………………………………………………………………………………………………………..138