Table of Contents

INTRODUCTION ………………………………………………………………………………………… 1
History of Hospital-at-Home ……………………………………………………………… 1
Favorable Outcomes and Reduced Complications in HaH …………………………… 5
Oncology Hospital-at-Home …………………………………………………………. 7
Statement of Purpose and Specific Aims …………………………………………….. 10
HYPOTHESIS…………………………………………………………………………………….. 11
METHODS ……………………………………………………………………… 12
Patient Selection ………………………………………………………………………… 12
Defining Suitability for HaH ……………………………………………………………….. 12
Data Preparation ……………………………………………………………………………. 14
Separation of Training and Validation Cohorts ……………………………………….. 15
Predictive Model Construction …………………………………………………………… 15
Assessment of the Predictive Models …………………………………………………… 17
Creation of Clinical Calculator …………………………………………………………….. 17
Author Contributions …………………………………………………………. 17
RESULTS …………………………………………………………….. 19
Suitability for HaH…………………………………………………………………….. 19
Creation of Derivation and Validation Cohorts ……………………………………….. 23
Predictive Model Creation ……………………………………………………………….. 25
Assessment of the Predictive Model ……………………………………………………………. 29
Creation of Clinical Calculator ……………………………………………………. 31
DISCUSSION ……………………………………………………………………………………… 32
APPENDIX:…………………………………………………………………………………….. 39
REFERENCES …………………………………………………………………………… 42