Table of Contents

Abstract
Acknowledgements.
Table of Contents
List of Tables
List of Figures
List of Abbreviations
List of Symbols
1. Introduction
1.1 Prostate IMRT
1.2 Prostate Localization Techniques
1.2.1 Prostate Localization, 4D
1.2.2 Prostate Localization, 3D
1.2.3 Prostate Localization, 2D
2. Imaging in Radiation Therapy
2.1 Computed Tomography
2.2 Cone Beam Computed Tomography
2.3 Planar Imaging
3. Adaptive Radiation Therapy
3.1 Rationale for Adaptive Radiation Therapy
3.2 Deformable Registration
4. Methods and Materials
4.1 Registration of Daily CBCT’s
4.2 Dose Recalculation and DVH Analysis
4.3 Dose Accumulation and DVH Analysis
5. Results
5.1 Daily DVH vs. Planned DVH
5.1.1 “Prostate 1”, Primary
5.1.2 “Prostate 1”, Boost
5.1.3 “Prostate 1”, Average Daily Deviation
5.1.4 “Prostate 2”
5.1.5 “Prostate 2”, Average Daily Deviation
5.2 Accumulated DVH vs. Planned DVH
5.2.1 “Prostate 1”, Primary
5.2.2 “Prostate 1”, Boost
5.2.3 “Prostate 1”, Composite
5.2.4 “Prostate 2”
6. Summary and Conclusions
6.1 Clinical Workflow
6.2 Contour Subjectivity
6.3 PTV Margins
6.4 Future Directions
References
Appendix A
Appendix B