Table of Contents

Abstract
Acknowledgments
Table of contents
List of tables
List of figures
1 – Literature Review
1.1 Breast cancer epidemiology, etiology and biologic subtypes
1.2 Estrogen biology
1.3 Adjuvant therapy in estrogen receptor positive breast cancer
1.4 Tamoxifen Endocrine therapy
1.5 Mechanisms of resistance to tamoxifen
1.6 Estrogen receptor structure and mechanism of action
1.7 Gene repression by estrogen and de-repression by tamoxifen
1.8 Carcinoma of lung, epidemiology and etiology
1.9 Classification and management of lung cancer
1.10 Pemetrexed in the treatment of NSCLC – single agent and combination therapy
1.11 Mechanism of action of pemetrexed
1.12 Mechanisms of resistance to pemetrexed
1.13 Therapeutic applications of glucocorticoids
1.14 Mechanism of action of the glucocorticoid receptor
1.15 Mechanisms of resistance to glucocorticoids
2 – Disruption of Estrogen Signaling Enhances Invasiveness of Breast Cancer Cells by Attenuating a Her2-independent Gene Repression Program
2.1 Abstract
2.2 Introduction
2.3 Materials and Methods
2.4 Results
2.5 Discussion
3 – Glucocorticoid Receptor Status is a Principal Determinant of Variability in the Sensitivity of Non-Small Cell Lung Cancer Cells to Pemetrexed
3.1 Abstract
3.2 Introduction
3.3 Materials and Methods
3.4 Results
3.5 Discussion
3.6 Acknowledgements
4 – Conclusion
References