Contents

Abstract
Acknowledgments
Contents
List of Figures
1. Introduction
1.1 Huntington’s Disease Overview
1.2 Mutant Huntingtin Protein in Huntington’s Disease
1.3 Current Pharmacotherapy for Huntington’s Disease
1.4 Role of Neurotrophic Factors in Huntington’s Disease
1.5 R6/2 Mouse Model of Huntington’s Disease
1.6 Aims and Objectives
2. Material and Methods
2.1 Subjects
2.2 Behavior Testing
2.3 Treatment Groups
2.4 Immunoblotting
2.5 Statistical Analysis
3. Results
3.1 Colivelin groups
3.2 Ceftriaxone groups
3.3 Sulforaphane groups
3.4 Effect of Treatment on Body Weight
4. Discussion
3.1 Colivelin groups
3.2 Ceftriaxone groups
3.3 Sulforaphane groups
3.4 Limitations of Study
5. Conclusion
6. References